Asymmetric Synthesis of (-)-(4R, 5R)-4-[5-(Benzo[1, 3]dioxol-5-yl)-4- hydroxyl-1-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl]benzamide

作     者：Xing Zhou LI Xian Ping DAI Jun Hai XIAO Song LI 

作者机构：Beijing Institute of Pharmacology ＆ Toxicology Beijing 100850 School of pharmaceutical Engineering Shenyang Pharmaceutical University Shengyang 110016 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2005年第16卷第9期

页      面：1137-1139页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by Chinese National Basic Developing Project(973 project:2004CB518908) 

主　　题：Asymmetric synthesis Juliá-Colonna epoxidation 1,3,5-triaryl-4-hydroxyl-4,5-dihydro-1H-pyrazole 

摘      要：The asymmetric synthesis of （-）-（4R, 5R）-4-[5-（benzo[1, 3]dioxol-5-yl）-4-hydroxyl-1- （pyridin-2-yl）-4,5-dihydro-lH-pyrazol-3-yl]-benzamide with improved Juliá-Colonna asymmetric epoxidation procedure as key step was described.