Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

作     者：Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 

作者机构：State Key Laboratory of Experimental HematologyNational Clinical Research Center for Blood DiseasesHematopoietic Stem Cell Transplantation CenterInstitute of Hematology and Blood Diseases HospitalPeking Union Medical College and Chinese AcademyTianjinChina Administration Office of BiostatisticsCenter for Information and ResourcesInstitute of Hematology and Blood Diseases HospitalPeking Union Medical College and Chinese AcademyTianjinChina Office of Institute of Hematology and Blood Diseases HospitalPeking Union Medical College and Chinese AcademyTianjinChina 

出 版 物：《Blood Science》 (血液科学（英文）)

年 卷 期：2022年第4卷第2期

页      面：83-88页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Natural Science Foundation of China(81670171 and 82070192) Key Project of Tianjin Natural Science Foundation(20JCZDJC00410) thrombocytopenia funding from the Yeehong Business School of Shenyang Pharmaceutical University(Sansheng TCP Young Research Funding,No.57) 

主　　题：Allogeneic hematopoietic stem cell transplantation Hemorrhagic cystitis Prognosis Risk factors 

摘      要：Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great *** study aimed to analyze risk factors of HC and its effect on patient *** collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August *** with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with *** used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC *** also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)*** propensity score matching,there were 131 patients each in the HC and non-HC *** the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)*** analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with ***,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate *** Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,*** analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of *** conclusion,when the BKV load is1×10^(7),we needtobe aware of the potential for