Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

作     者：Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang Hirotaka Ejima Junling Guo Changsheng Zhao 

作者机构：College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan610065China BMI Center for Biomass Materials and NanointerfacesCollege of Biomass Science and EngineeringSichuan UniverisityChengduSichuan610065China Laboratory Animal CenterSichuan UniversityChengduSichuan610065China School of Chemical EngineeringGraduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesSydneyNSW2052Australia Department of Materials EngineeringSchool of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113􀀀8656Japan Bioproducts InstituteDepartments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada School of Chemical EngineeringSichuan UniversityChengduSichuan610065China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第10期

页      面：95-106页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the National Natural Science Foundation of China(Grant No.51903168,51673125,and 51873115) State Key Research Development Programme of China(Grant Nos.2016YFC1103000 and 2018YFC1106400) International Visiting Program for Excellent Young Scholars of Sichuan University,and the China Postdoctoral Science Foundation(2018M643485) The work in the J.G.laboratory was financially supported by the National Global Talents Recruitment Program(J.G.),National Natural Science Foundation of China(J.G.,Grant No.22178233)State Key Laboratory of Polymer Materials Engineering(J.G.,Grant No.sklpme2020-3-01) Double First Class University Plan(J.G.) Key Laboratory of Leather Chemistry and Engineering(J.G.) National Engineering Research Center of Clean Technology in Leather Industry(J.G.). 

主　　题：Metal-phenolic network Wound healing Antibacterial activity Revascularization 

摘      要：New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital importance.Although antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are scarce.Herein,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular layer.This synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal tissue.In infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo models.In other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.