Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain
作者机构：Neuroscience Research InstitutePeking UniversityBeijing 100191China Department of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for NeuroscienceMinistry of EducationNational Health CommissionPeking UniversityBeijing 100191China Wuxi HANS Health Medical Technology Co.Ltd.Wuxi 214122China Department of Integration of Chinese and Western MedicineSchool of Basic Medical SciencesPeking UniversityBeijing 100191China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第4期
页 面：403-416页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：supported by the National Key Research and Development Program of the Ministry of Science and Technology China(2016YFC0105501 2019YFD1712000).
主 题：SCS Analgesia Opioid receptors Methionine-Enkephalin Dynorphin Endorphins
摘 要：Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor thresholds.Various frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly effective.SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation.SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid.The analgesic effect of 2 Hz was abolished byμorκopioid receptor antagonist.The effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.
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