Recombination of repeat elements generates somatic complexity in human genomes
作者机构：RIKEN Center for Integrative Medical Sciences (IMS) Yokohama 230-0045 Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Kashiwa 277-8562 Chiba Japan Department of Medicine University of California San Diego La Jolla CA 92093 USA Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm 171 77 Sweden Department of Neuropathology Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (TMGHIG) Tokyo 173-0015 Japan Central RNA Laboratory and Department of Neuroscience and Brain Technologies Istituto Italiano di Tecnologia (IIT) Genova 16163 Italy Artificial Intelligence Research Center National Institute of Advanced Industrial Science and Technology (AIST) Tokyo 135-0064 Japan
出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)
年 卷 期：2022年第44卷第7期
页 面：1291-1291页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Ministry of Education, Culture, Sports, Science and Technology, MEXT RIKEN Japan Agency for Medical Research and Development, AMED, (JP19dm0107106) Japan Society for the Promotion of Science, JSPS, (JP16H06277, 22K07538)
主 题：determination. elements companies
摘 要：Non-allelic recombination between homologous repetitive elements contributes to evolution and human genetic ***,we combine short-and long-DNA read sequencing of repeat elements with a new bioinformatics pipeline to show that somatic recombination of Alu and L1 elements is widespread in the human *** analysis uncovers tissue-specific non-allelic homologous recombination hallmarks;moreover,we find that centromeres and cancer-associated genes are enriched for retroelements that may act as recombination *** compare recombination profiles in human-induced pluripotent stem cells and differentiated neurons and find that the neuron-specific recombination of repeat elements accompanies chromatin changes during cell-fate determination.
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