Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia

作     者：Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu Shuya Wang Bing Zhu Xinyan Gao 

作者机构：Department of PhysiologyInstitute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Research Center of Traditional Chinese MedicineThe Affiliated Hospital of Changchun University of Chinese MedicineChangchunJilin 130021China Department of CardiologyJining No.1 People’s HospitalJining 272100ShandongChina Department of Needling ManipulationInstitute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2022年第38卷第4期

页      面：386-402页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Key R&D Program of China(2018YFC1704600) the National Natural Science Foundation of China(81674085,81904309). 

主　　题：Sympathetic-sensory coupling Neuromodulation Referred pain α_(2)adrenoceptor Cardioprotectio 

摘      要：Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain unclear.Here,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory coupling.Moreover,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished sympathoexcitation.Intradermal injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ES.Overall,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.