The instability of a stable metal-organic framework in amino acid solutions
作者机构：Department of ChemistryZhejiang UniversityHangzhou 310027China Department of RehabilitationSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310027China Key Laboratory of Excited-State Materials of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第7期
页 面：6607-6612页
核心收录：
学科分类：0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0901[农学-作物学] 0703[理学-化学] 0836[工学-生物工程]
基 金：supported by the National Natural Science Foundation of China(Nos.21922410,22072133,and 21673206) Zhejiang Provincial Natural Science Foundation(No.LR19B050001) the Leading Innovation and Entrepreneurship Team of Zhejiang Province(No.2020R01003).
主 题：metal-organic frameworks stability amino acids solid-state nuclear magnetic resonance(NMR) biomedical applications
摘 要：Metal–organic frameworks(MOFs)are being investigated as the potential materials for future drug delivery and gene therapy systems thanks to their tunable functionality and biocompatibility.However,the structure of MOFs could be altered in a biological environment or in a buffer solution.It is of great importance to evaluate the stability of MOFs and understand the degradation processes for the sake of the biomedical applications.In this work,we investigate the stability of UiO-66,a generally-perceived stable MOF,in different amino acid solutions.We find that UiO-66 loses crystallinity in relatively mild basic conditions(when pH≥9)in the presence of amino acids.The instability is more pronounced in the lysine and arginine solutions which have stronger basicity.It can be attributed to the accelerated ligand exchange of UiO-66 under basic conditions.With a combination of techniques,we show that the amino acids can replace the organic linkers and form zirconium-amino acid complexes.Our research reveals one possible mechanism of MOF degradation in biological environment,yet such degradability could be also an important designable property for MOFs in biomedical applications.
维普期刊数据库