SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies

作     者：Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu Mingzhu Huang Xiaoling Su Bijia Lin Pengxing Cao Ji Yang Pixin Ran 

作者机构：State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina The Second People’s Hospital of ChangdeHunanChina School of mathematics and StatisticsUniversity of MelbourneMelbourneVICAustralia 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1773-1782页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：This work was supported by the State Key Basic Research Project,Ministry of Science and Technology of P.R.China(2019YFC0810903,2021YFC0864400) NSFC 81971485,Guangdong Key Basic Research Project(2019B1515120068 and 2020B1111330001) the Zhongnanshan Medical Foundation of Guangdong Province(ZNSA2020013)。 

主　　题：antibodies neutral assessing 

摘      要：Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination plans.Here,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody clusters.We found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG.