Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

作     者：Xinxin Xiong Siyu Chen Jianfei Shen Hua You Han Yang Chao Yan Ziqian Fang Jianeng Zhang Xiuyu Cai Xingjun Dong Tiebang Kang Wende Li Penghui Zhou 

作者机构：State Key Laboratory of Oncology in Southern ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510515China Guangdong Laboratory Animals Monitoring InstituteGuangdong Key Laboratory of Laboratory AnimalsGuangzhou 510663China Department of Thoracic SurgeryTaizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000China Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Thoracic SurgerySun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210023China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1657-1669页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study is supported by grants from the National Key Research and Development Program of China(2016YFA0500304) the National Nature Science Foundation in China(NSFC)(81802853,81802854,81773052,81572806) the Postdoctoral Science Foundation in China(2018M633237) the Guangzhou Science Technology and Innovation Commission(201607020038) the Natural Science Foundation of Guangdong Province(2017A030308007) the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S638) the Leading Talents Program of Guangdong Province(2016LJ06S464). 

主　　题：JAK/STAT drugs chemotherapy treatment 

摘      要：The combination of immune checkpoint blockade(ICB)with chemotherapy significantly improves clinical benefit of cancer treatment.Since chemotherapy is often associated with adverse events,concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy.However,whether these ancillary drugs could impede immunotherapy remains unknown.Here,we showed that∆9-tetrahydrocannabinol(THC),the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea,reduced the therapeutic effect of PD-1 blockade.The endogenous cannabinoid anandamide(AEA)also impeded antitumor immunity,indicating an immunosuppressive role of the endogenous cannabinoid system(ECS).