Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography

作     者：Yuanyuan Jiang Zijian Deng Dan Yang Xin Deng Qi Li Yinlin Sha Changhui Li Dongsheng Xu 

作者机构：Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China Single-molecule and Nanobiology Laboratory Department of Biophysics School of Basic Medical Sciences and Biomed-X Center Peking University Beijing 100191 China These authors contributed equally to this work. 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2015年第8卷第7期

页      面：2152-2161页

核心收录：

学科分类：07[理学] 

主　　题：nanoparticles,gold nanoflowers,contrast agents,photoacoustic tomography tumor imaging,molecular imaging 

摘      要：By binding molecular probes that target tumor cells, gold nanoparticles （AuNPs） with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers （AuNFs） are presented as a novel contrast agent for photoacoustic tomography （PAT）. By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional （3D） PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging.