Diverse strategic approaches en route to Taxol total synthesis

作     者：Zexian Li Jianfeng Zheng Wei-Dong Z.Li Zexian Li;Jianfeng Zheng;Wei-Dong Z.Li

作者机构：Sichuan Engineering Research Center for Biomimetic Synthesis of Natural DrugsSchool of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第12期

页      面：4957-4968页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：support from the National Natural Science Foundation of China(Nos.21901215,21672030) the Fundamental Research Funds for the Central Universities(No.2682021CG020) 

主　　题：Taxol Total synthesis Biomimetic synthesis Linear strategy Convergent strategy 

摘      要：Taxol is one of the most famous diterpenoid natural products used in clinical cancer *** and its analogues are popular synthetic targets and have attracted worldwide attention over the past *** research efforts have already been made and ten groups have achieved the total synthesis of Taxol since *** mini-review summarized the recent highlights of divergent strategic approaches towards the chemical synthesis of Taxol s carbocyclic framework bearing a bridged eight-membered ring.