Omicron:Master of immune evasion maintains robust ACE2 binding

作     者：Markus Hoffmann Lu Zhang Stefan Pohlmann 

作者机构：Infection Biology UnitGerman Primate Center—Leibniz Institute for Primate ResearchGöttingenGermany Georg-August-University GöttingenGöttingenGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1360-1362页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：The Pöhlmann lab was supported by funds from the Bundesministerium für Bildung und Forschung(BMBF projects 01KI2006D,01KI20328A,01KX2021) Deutsche Forschungsgemeinschaft(DFG,PO 716/14-1,PO 716/11-1)and Niedersächsisches Ministerium für Wissenschaft und Kultur(COFONI Network) Z.L.was supported by the China Scholarship Council(CSC)(202006270031). 

主　　题：ACE2 maintain 

摘      要：The spike(S)protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear.A recent study published in Science by Mannar et al.now shows that these mutations are compatible with robust ACE2 binding and allow for efficient evasion of neutralizing antibodies.The emergence of SARS-CoV-2 variants has become a hallmark of the COVID-19 pandemic.Variants of concern(VOC)harbor mutations in the viral S protein that can increase transmissibility,potentially by promoting S protein binding to the cellular receptor ACE2.