Artificially regulated synthesis of nanocrystals in live cells
Artificially regulated synthesis of nanocrystals in live cells作者机构：State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic MatterResearch Center for Analytical SciencesCollege of ChemistrySchool of MedicineFrontiers Science Center for Cell Responses Nankai University College of Chemistry and Molecular Sciences Wuhan University
出 版 物：《National Science Review》 (国家科学评论(英文版))
年 卷 期：2022年第9卷第6期
页 面：189-199页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学]
基 金：supported by the National Key R&D Program of China (2019YFA0210100) the National Natural Science Foundation of China (91859123) the ‘Frontiers Science Center for New Organic Matter’,Nankai University (63181206) the‘Fundamental Research Funds for the Central Universities’,Nankai University (63201024) the Tianjin Natural Science Foundation (19JCQNJC02400)
主 题：cell synthesis nanocrystal quantum dot artificial metabolism
摘 要：Live cells, as reservoirs of biochemical reactions, can serve as amazing integrated chemical plants where precursor formation, nucleation and growth of nanocrystals, and functional assembly, can be carried out accurately following an artificial program. It is crucial but challenging to deliberately direct intracellular pathways to synthesize desired nanocrystals that cannot be produced naturally in cells, because the relevant reactions exist in different spatiotemporal dimensions and will never encounter each other *** article summarizes the progress in the introduction of inorganic functional nanocrystals into live cells via the ‘artificially regulated space–time-coupled live-cell synthesis’ strategy. We also describe ingenious bio-applications of nanocrystal–cell systems, and quasi-biosynthesis strategies expanded from live-cell synthesis. Artificially regulated live-cell synthesis—which involves the interdisciplinary application of biology, chemistry, nanoscience and medicine—will enable researchers to better exploit the unanticipated potentialities of live cells and open up new directions in synthetic biology.
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