Model construction and numerical simulation of arterial remodeling after stent implantation with variations of cell concentration

作     者：Yu Zhang Shiliang Chen Hanbing Zhang Chenyang Ma Tianming Du Aike Qiao 

作者机构：Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical TransformationBeijing University of TechnologyBeijing100124China 

出 版 物：《Medicine in Novel Technology and Devices》 (医学中新技术与新装备（英文）)

年 卷 期：2022年第16卷第4期

页      面：51-59页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：National Natural Science Foundation of China Joint program of Beijing Municipal-Beijing Natural Science Foundation[KZ202110005004] China Postdoctoral Science Foundation[No.2021TQ0020] 

主　　题：Numerical simulation Agent-based model Finite element method Vascular remodeling Cell concentration 

摘      要：Differences in concentration of molecules can cause different molecular *** issue has not been well studied in the vascular remodeling process with regards to is-stent *** study designed and built a model to explore the effect of differences in vascular cell concentration on vascular *** element analysis(FEA)models and the agent-based models(ABMs)were established to simulate the damage and proliferation process of vascular smooth muscle cells(VSMCs)caused by coronary artery stent *** FEA model simulated the expansion of the stent in the coronary artery,the tensile stress was captured and imported into the ABM,and the damaged VSMCs proliferated to reduce their damage *** were randomly distributed within a defined domain,and the number of VSMCs in a unit volume(or area)was defined as the concentration of *** with the smallest concentration of VSMCs will preferentially proliferate,which simulates the cell proliferation affected by the concentration of *** results showed that after stent implantation,VSMCs proliferated gradually from the severely damaged stent area to the lumen until the artery reached a steady *** comparison,the loss of arterial lumen and the number of newly grown VSMCs were greater in the presence of the concentration than in its *** made full use of the lumen space under the influence of concentration differences,so the concentration was of great significance to vascular remodeling.