Novel lactic acid bacteria with anti-hyperuricemia ability:Screening and in vitro probiotic characteristics

作     者：Jia-Xin Lin Tao Xiong Zhen Peng Mingyong Xie Fei Peng 

作者机构：School of Food Science and TechnologyNanchang UniversityNo.235 Nanjing East RoadNanchangJiangxi330047PR China State Key Laboratory of Food Science and TechnologyNanchang UniversityNo.235 Nanjing East RoadNanchangJiangxi330047PR China 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2022年第49卷第5期

页      面：181-187页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The National Natural Science Foundation of China(32101894 32160547) National Key Research and Development Program of China(2017YFD0400503-3) Vegetable Industry Technology System Post Expert Project of Jiangxi Province(JXARS-06),Major Special Science and Technology Project of Yunnan Province(202002AE320006) Research Project of State Key Laboratory of Food Science and Technology,Nanchang University(SKLF-ZZA-201910,SKLF-ZZB-202132)are gratefully acknowledged 

主　　题：Lactic acid bacteria Anti-Hyperuricemia Probiotic characteristics Principal component analysis β-D-glucosidase activity 

摘      要：Hyperuricemia has been identified as the second most common metabolic disease,increasing the incidence of gout,hypertension,kidney disease,and cardiovascular *** acid bacteria have been attracting considerable interest in anti-hyperuricemia given various probiotic *** this study,sixteen lactic acid bacteria were selected from one hundred ninety-two isolates through whole-cell catalysis,affordingβ-D-glucosidase activity of 0.1652-0.3346 U/mg wet cells,degradation rate of inosine-transformed rate of 1.2125-4.6555 mM/h and guanosine-transformed rate of 0.2904-1.8303 mM/*** sixteen candidates’acid tolerance,bile resistance,hydrophobicity,and auto-aggregation were further *** to the results of the seven indexes,the five top-scored strains were viewed as the potentially functional probiotics for anti-hyperuricemia via the comprehensive evaluation of principal component *** assay showed that the adhesion of the five strains to Caco-2 cells ranged from 2.67%to 8.67%.Moreover,the five strains can decrease the adhesion of *** to Caco-2 cells by 36.67-98.73%through competition inhibition,exclusion inhibition,and replacement ***,the five probiotics were sensitive to some of the antibiotics examined and were innocuous with nonhemolytic *** preliminary works indicate that the five candidates could show a good potential application against hyperuricemia.