Numerical Simulation on Thermal Response of Laser-Irradiated Biological Tissues Embedded with Liquid Metal Nanoparticles

作     者：WANG Dawei RAO Wei WANG Dawei;RAO Wei

作者机构：CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Cryo-Biomedical EngineeringTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Journal of Thermal Science》 (热科学学报（英文版）)

年 卷 期：2022年第31卷第4期

页      面：1220-1235页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0714[理学-统计学（可授理学、经济学学位）] 0803[工学-光学工程] 0701[理学-数学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：the National Key R&D Program of China(No.2018YFC1705106) National Natural Science Foundation of China(No.51890893)。 

主　　题：Monte-Carlo simulation Penne's bioheat transfer model transformable liquid metal nanoparticles NIR laser photothermal therapy 

摘      要：Photothermal therapy is emerging as a very promising way for minimally invasive cancer treatment.To enhance thermal energy deposition of laser in target malignant tissues,liquid metal nanoparticles(LMNPs)have been recently identified as completely unprecedented photothermal sensitizers due to their unique physicochemical properties and superior photothermal conversion rate under near-infrared(NIR)laser irradiation.However,there is currently a strong lack of understanding of the laser energy distribution and the transient temperature field within the biological tissues,which would seriously hinder the development of LMNPs assisted photothermal therapy.Therefore,this paper focused on the distinctive photothermal effect of LMNPs embedded in biological tissues under NIR laser irradiation.The mathematical model coupling the Monte-Carlo photon transport model with Penne s bioheat transfer model has been established.Simulation studies have shown that LMNPs play an important role in enhancing the absorption of NIR laser,which contributes to local temperature rise and improves the temperature distribution.Comparing with the control case without LMNPs,the maximum temperature increases by nearly 1.0 time,the local temperature rise reaches 30℃ in 1.0 second.When the diameter and concentration of LMNPs are 40 nm and 1012/mm3,the resulting temperature variation and distribution is best for the effective killing of tumors without damaging normal tissues.In addition,the simulation results are meaningful for guiding the selection of laser irradiation time in conjunction with the cooling time,ensuring the controllable accuracy of treatment.To the best of our knowledge,the present study is one of the first attempts to quantify the influence of transformable LMNPs on the temperature distributions inside the biological tissues,showing important academic significance for guiding LMNPs assisted photothermal treatment.