Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma

作     者：Ying Liu Yu Han Shizhu Chen Jingjie Liu Dajiang Wang Yifei Huang Ying Liu;Yu Han;Shizhu Chen;Jingjie Liu;Dajiang Wang;Yifei Huang

作者机构：Department of OphthalmologyBeijing Rehabilitation HospitalCapital Medical UniversityBeijing 100144China Department of OphthalmologyChinese PLA General HospitalBeijing 100853China College of Chemistry&Environmental ScienceChemical Biology Key Laboratory of Hebei ProvinceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071002China China Resources Pharmaceutical Group LimitedBeijing 100000China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第6期

页      面：2731-2739页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financially supported by National Natural Science Foundation of China(7212092,81770887) China Postdoctoral Science Foundation(2019M650558) Beijing Postdoctoral Research Foundation Beijing Chaoyang District Postdoctoral Research Foundation。 

主　　题：Nanoplatform Liposomes Retinoblastoma Imaging-guided Photothermal therapy 

摘      要：Photothermal therapy has the characteristics of minimal invasiveness,controllability,high efficiency,and strong specificity,which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment.However,due to the limited tissue penetration of infrared light,it is difficult to promote and apply in clinical practice.The eye is the only transparent tissue in human,and infrared light can easily penetrate the eye tissue,so it is expected that photothermal therapy can be used to treat fundus diseases.Here in,a new nano-platform assembled by liposome and indocyanine green(ICG) was used to treat retinoblastoma.ICG was assembled in liposomes to overcome some problems of ICG itself.For example,ICG is easily quenched,self-aggregating and instability.Moreover,liposomes can prevent free ICG from being cleared through the systemic circulation.The construction of the nano-platform not only ensured the stability of ICG in vivo,but also realized imaging-guide photothermal therapy,which created a new strategy for the treatment of retinoblastoma.