Chlamydia trachomatis infection in the genital tractis associated with inflammation and hypospermia inthe infertile male of China
作者机构：Department of Obstetrics and GynecologyKey Laboratory for Major Obstetric Diseases of Guangdong ProvinceThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China Key Laboratory of Reproduction and Genetics of Guangdong Higher Education InstitutesThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China Kingmed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou 510182China Department of Clinical LaboratoryThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第1期
页 面：56-61页
核心收录：
基 金：This work was supported by grants from the Guangzhou City Science,Technology and Innovation Commission(No.201804010340 and 202002030077) National Natural Science Foundation of China(No.82002774 and 81401206) Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010065) Guangdong Province Outstanding Youth Medical Talent Program(No.110217110) Liwan District Science and Technology Planning Project(No.201804013) The Third Affiliated Hospital of Guangzhou Medical University Elite Talent Fund Project(No.110217103).
主 题：Chlamydia trachomatis genital tract obstruction hypospermia male infertility semen parameters sperm quality
摘 要：Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlikethat in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective studywas to explore the impacts of CT infection in the genital tract on sperm quality, sperm acrosin activity, antisperm antibody levels,and inflammation in a large cohort of infertile males in China. A total of 7154 semen samples were collected from infertile malesubjects, 416 of whom were CT positive (CT+ group) and 6738 of whom were CT negative (CT− group), in our hospital betweenJanuary 2016 and December 2018. Routine semen parameters (semen volume, pH, sperm concentration, viability, motility,morphology, etc.), granulocyte elastase levels, antisperm antibody levels, and sperm acrosin activity were compared between theCT+ and CT− groups. Our results showed that CT infection was significantly correlated with an abnormally low semen volume, aswell as an increased white blood cell count and granulocyte elastase level (all P 0.05) in the semen of infertile males;otherroutine semen parameters were not negatively impacted. The antisperm antibody level and sperm acrosin activity were not affectedby CT infection. These findings suggested that CT infection might contribute to inflammation and hypospermia but does not impairsperm viability, motility morphology, and acrosin activity or generate antisperm antibodies in the infertile males of China.
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