Recent advances in neutrophil chemotaxis abnormalities during sepsis

作     者：Yu-Ying Zhou Bing-Wei Sun Yu-Ying Zhou;Bing-Wei Sun

作者机构：Department of Burns and Plastic SurgeryAffiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2022年第25卷第6期

页      面：317-324页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.82072217,81772135 and U21A20370) the Jiangsu Natural Science Foundation(No.BK20201178)。 

主　　题：Sepsis Neutrophil Chemotaxis Dysfunction Migration 

摘      要：Sepsis remains one of the leading causes of death globally,in spite of advanced developments in intensive care and better understandings of pathophysiology related to sepsis.There is no special treatment or drug available for sepsis,currently.Under normal circumstances,neutrophil is a major player in acute infection control.However,during sepsis,the migration abilities and antimicrobial functions of neutrophils are impaired,resulting in a dysregulated immune response.Recent studies have indeed demonstrated that blocking or reversing neutrophil migration and impaired antibacterial function can improve the outcomes in septic animal models.This article systemically synthesized information regarding related factors and signaling involved in the functions of neutrophils in sepsis.This review also discussed the possibility that neutrophils be used as a marker for specific diagnosis and/or prediction of the outcomes of sepsis.