Effects of glucocorticoids on leukocytes:Genomic and non-genomic mechanisms

作     者：Wan-Yu Jia Jian-Jiang Zhang 

作者机构：Department of PediatricsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Clinical Center of Pediatric Nephrology of Henan ProvinceThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第21期

页      面：7187-7194页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by Provinces Co-construction Program of Medical Science and Technique Foundation of Henan Province,No.SB201901042 Key Scientific Research Project of Colleges and Universities in Henan Province,No.21A320070 

主　　题：Glucocorticoid Leukocyte Count Functions Glucocorticoid receptor 

摘      要：Glucocorticoids(GCs)have been widely used as immunosuppressants and antiinflammatory agents to treat a variety of autoimmune and inflammatory diseases,and they fully exert their anti-inflammatory and immune-regulating effects in the *** effect of GCs on white blood cells is an important part of their *** can cause changes in peripheral blood white blood cell counts by regulating the proliferation,differentiation,and apoptosis of white blood *** the total number of white blood cells,neutrophil counts,lymphocytes,and eosinophils increases,the counts of basic granulocytes and macrophages *** addition,GCs can regulate the activation and secretion of white blood cells,inhibit the secretion of a variety of pro-inflammatory cytokines,the expression of chemokines,and promote the production of anti-inflammatory *** patients on GC therapy,the effects of GCs on leukocytes were similar to the changes in peripheral blood caused by bacterial ***,we suggest that clinicians should be more cautious in assessing the presence of infection in children with long-term use of GCs and avoid overuse of antibiotics in the presence of elevated *** work through genomic and non-genomic mechanisms in the human body,which are mediated by GC *** recent years,studies have not fully clarified the mechanism of GCs,and further research on these mechanisms will help to develop new therapeutic strategies.