Gut microbiota:a new insight into neurological diseases

作     者：Lanxiang Liu Haiyang Wang Xueyi Chen Peng Xie 

作者机构：Department of NeurologyYongchuan Hospital of Chongqing Medical UniversityChongqing 402160China National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional DiseasesThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第11期

页      面：1261-1277页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：National Key R&D Program of China(No.2017YFA0505700) Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2019PT320002) Natural Science Foundation Project of China(No.81820108015) China Postdoctoral Science Foundation(Nos.2020TQ0393,2020M683634XB,and 2021M693926) Chongqing Science and Technology Commission(Nos.cstc2021jcyj-bsh0026 and cstc2021jcyj-bsh0034) 

主　　题：Gut microbiota Gut-brain axis Neurological diseases Parkinson’s disease Alzheimer’s disease Autism spectrum disorder Cerebrovascular disease 

摘      要：In the last decade,it has become increasingly recognized that a balanced gut microbiota plays an important role in maintaining the health of the *** clinical and preclinical studies have shown that changes in gut microbiota composition are associated with a variety of neurological diseases,e.g.,Parkinson’s disease,Alzheimer’s disease,and myasthenia ***,the underlying molecular mechanisms are complex and remain *** phenotypes can be transmitted from humans to animals through gut microbiota transplantation,indicating that the gut microbiota may be an important regulator of neurological ***,further research is required to determine whether animal-based findings can be extended to humans and to elucidate the relevant potential mechanisms by which the gut microbiota regulates neurological *** investigations may aid in the development of new microbiota-based strategies for diagnosis and treatment and improve the clinical management of neurological *** this review,we describe the dysbiosis of gut microbiota and the corresponding mechanisms in common neurological diseases,and discuss the potential roles that the intestinal microbiome may play in the diagnosis and treatment of neurological disorders.