CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children

作     者：Hui-ran LIN Yong-ping CHEN Hui-tong CHEN Xiao-ping LIU Jing-ying ZHOU Xiao-kai HUANG Li YUAN Zhen-jian ZHUO Hui-ran LIN;Yong-ping CHEN;Hui-tong CHEN;Xiao-ping LIU;Jing-ying ZHOU;Xiao-kai HUANG;Li YUAN;Zhen-jian ZHUO

作者机构：Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Department of Pediatric SurgeryGuangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of HematologyGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Hematologythe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027China Department of PathologyGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2022年第42卷第4期

页      面：797-802页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by grants from the Natural Science FoundationofGuangdongProvince(No.2020A1515010188) the National Natural Science Foundation of China(Nos.81802346 and 81672496) the Science and Technology Project of Guangzhou(No.201804010042). 

主　　题：cancer susceptibility candidate 15 polymorphisms glioma susceptibility Chinese 

摘      要：Objective:Gliomas are the most common tumors in the central nervous system.The cancer susceptibility candidate 15(CASC15)gene has been reported to be a susceptibility gene for several types of cancer.No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide polymorphisms(SNPs)on glioma risk.Methods:In order to determine whether CASC15 gene SNPs are involved in glioma susceptibility,the first association study in a relatively large sample,which consisted of 171 patients and 228 healthy controls recruited from China,was performed.The contribution of SNPs(rs6939340 AG,rs4712653 TC and rs9295536 CA)to the risk of glioma was evaluated by multinomial logistic regression,based on the calculation of the odds ratio(OR)and 95%confidence interval(CI).Results:In the single locus and combined analysis,it was revealed that the genetic risk score had no significant associations between CASC15 gene SNPs and glioma risk.However,in the stratified analysis,a significant decrease in risk of glioma was observed in subjects of60 months old with the rs4712653 TT genotype,when compared to those with the CC/CT genotype(OR=0.12,95%CI=0.02-0.91,P=0.041).Conclusion:The present study provides referential evidence on the association between the genetic predisposition of the CASC15 gene and glioma risk in Chinese children.However,more well-designed case-control studies and functional experiments are needed to further explore the role of CASC15 gene SNPs.