Interferon-beta inhibits human glioma stem cell growth by modulating immune response and cell cycle related signaling pathways
作者机构：Shanghai Key Laboratory of Craniomaxillofacial Development and DiseasesShanghai Stomatological Hospital&School of StomatologyFudan UniversityShanghaiChina Institute of PhotomedicineShanghai Skin Disease HospitalTongji University School of MedicineShanghaiChina School of MedicineJiaxing UniversityJiaxingChina Tongji University Cancer CenterShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Department of NeurosurgeryChangzheng HospitalSecond Military Medical UniversityShanghaiChina Department of NeurosurgeryThird Affiliated Hospital of Second Military Medical UniversityShanghaiChina
出 版 物：《Cell Regeneration》 (细胞再生（英文）)
年 卷 期：2022年第11卷第1期
页 面：212-226页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by funds from the National Natural Science Foundation of China[31600819 to CCH,81901031 to HXX,32070862 and 31571058 to GZL] the Shanghai Municipal Population and Family Planning Commission[20174Y0216 to CCH] the Natural Science Foundation of Shanghai[19ZR1445400 to HXX] the National Key R&D Program of China[2019YFA0110300] the Shanghai Easter Scholar[8101219003 to GZL]
主 题：Glioma stem cells IFN-β Neural stem cell Cell cycle Immune response
摘 要：Malignant Glioma is characterized by strong self-renewal potential and immature differentiation *** main reason is that malignant glioma holds key cluster cells,glioma stem cells(GSCs).GSCs contribute to tumorigenesis,tumor progression,recurrence,and treatment ***-beta(IFN-β)is well known for its anti-proliferative efficacy in diverse ***-βalso displayed potent antitumor effects in malignant ***-βaffect both GSCs and Neural stem cells(NSCs)in the treatment of ***,the functional comparison,similar or different effects of IFN-βon GSCs and NSCs are rarely ***,we studied the similarities and differences of the responses to IFN-βbetween human GSCs and normal *** found that IFN-βpreferentially inhibited GSCs over *** cell body and nucleus size of GSCs increased after IFN-βtreatment,and the genomic analysis revealed the enrichment of the upregulated immune response,cell adhesion genes and down regulated cell cycle,ribosome *** typical cyclin genes,including cyclin A2(CCNA2),cyclin B1(CCNB1),cyclin B2(CCNB2),and cyclin D1(CCND1),were significantly downregulated in GSCs after IFN-β*** also found that continuous IFN-βstimulation after passage further enhanced the inhibitory *** study revealed how genetic diversity resulted in differential effects in response to IFN-β*** results may contribute to improve the applications of IFN-βin anti-cancer *** addition,these results may also help to design more effective pharmacological strategies to target cancer stem cells while protecting normal neural stem cells.
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