Viral shedding in Chinese young adults with mild 2009 H1N： influenza

作     者：JIA Ning GAO Yan SUO Ji-jiang XIE Li-jun YAN Zhong-qiang XING Yu-bin HE Lei LIU Yun-xi 

作者机构：Department of Nosocomial Infection and Disease Control People's Liberation Army General Hospital Beijing 100853. China Department of Police Research People's Liberation Army General Hospital Beijing 100853. China Department of Hepatobiliary Surgery People's Liberation Army General Hospital Beijing 100853. China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第10期

页      面：1576-1579页

核心收录：

学科分类：10[医学] 

基　　金：This study was partly supported by a grant from the National Natural Science Fundation of China 

主　　题：H1N1 influenza virus infection viral shedding 

摘      要：Background The duration of viral shedding and the transmission of 2009 H1N1 influenza among individuals, especially among the younger population with mild illness, are not well understood now. The aim of this study was to determine the viral shedding of the young adult patients with mild 2009 H1N1 influenza in *** From September 2009 to January 2010, the clinical data and serial nasopharyngeal swabs of 67 patients with 2009 H1N1 influenza and 37 patients with seasonal influenza aged from 18 years to 35 years were collected. The nasopharyngeal swab samples were detected by real time RT-PCR to determine the viral shedding. All the patients did not receive the antiviral therapy but Chinese medicine for *** Among the patients with H1N1 virus infection, 82.1% （55/67） patients presented with fever symptom, while more patients with high fever （≥39℃） were found in seasonal influenza patients （P〈0.05）. For the H1N1 patients, the median interval between the symptom onset and the undetectable RNA was six days （4-10 days）. But viral shedding was still found in 31.3% patients after 7 days following illness onset. The median interval between disappearance of fever and an undetectable viral RNA level was three days （2-8 days）, and 17.9% patients were found to be viral shedding 6 days later after normalization of body temperature. For the seasonal influenza patients, 94.6% patients were detected out viral RNA within 7 days. The median interval of seasonal influenza between the symptom onset and the undetectable RNA was four days （3-8 days）. The median interval between disappearance of fever and an undetectable viral RNA level was three days （2-6 days）.Conclusion It suggests that 7 days isolation period from the illness onset or 24 hours after the resolution of fever and respiratory symptoms are not long enough to cut off the transmission among Chinese young adults with mild illness