Analysis of the mechanism of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure based on network pharmacology
作者机构：Heilongjiang University of Traditional Chinese MedicineHarbin 150040China The First Affiliated Hospital of Heilongjiang University of Traditional Chinese MedicineHarbin 150040China
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2022年第28卷第9期
页 面：41-47页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Fund Project:Youth Science Fund Project of National Natural Science Foundation of China(No.81904107) Scientific Research Fund of Heilongjiang University of Traditional Chinese Medicine(No.2019TD01)
主 题：Radix Astragali-Radix Pseudostellariae Chronic heart failure Network pharmacology Targets Mechanism of action
摘 要：Objective:To explore and analyze the effective component,target and mechanism of action of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure(CHF)by network pharmacological research ***:With the help of TCMSP database,the effective chemical constituents and targets of Radix Astragali-Radix Pseudostellariae were screened out,and CHF-related proteins were obtained by Gene Cards and OMIM *** target protein interaction network(PPI)was constructed on the String database platform,and using DAVID database to conduct the GO function and KEGG pathway enrichment analysis on the target of the obtained astragalus-pseudostellariae for the treatment of ***:Radix Astragali-Radix Pseudostellariae were selected as 28 effective chemical components and 104 therapeutic targets for *** were obtained 49 GO functional annotations and 86 KEGG signaling ***:Radix Astragali-Radix Pseudostellariae can treat CHF through multi-target and multi-pathway.
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