Multiple roles for cholinergic signaling in pancreatic diseases
作者机构：Department of GastroenterologyThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第25期
页 面：2910-2919页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by National Natural Science Foundation of China No.82100686
主 题：Acetylcholine Muscarinic receptors Nicotinic receptors Pancreatic exocrine Pancreatitis Pancreatic cancer
摘 要：Cholinergic nerves are widely distributed throughout the human body and participate in various physiological activities,including sensory,motor,and visceral activities,through cholinergic *** signaling plays an important role in pancreatic exocrine secretion.A large number of studies have found that cholinergic signaling overstimulates pancreatic acinar cells through muscarinic receptors,participates in the onset of pancreatic diseases such as acute pancreatitis and chronic pancreatitis,and can also inhibit the progression of pancreatic ***,cholinergic signaling plays a role in reducing pain and inflammation through nicotinic receptors,but enhances the proliferation and invasion of pancreatic tumor *** review focuses on the progression of cholinergic signaling and pancreatic diseases in recent years and reveals the role of cholinergic signaling in pancreatic diseases.
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