Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis

作     者：Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu 

作者机构：Nanjing UniversityCollege of Engineering and Applied SciencesNanjingChina Nanjing UniversityNational Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjingChina Nanjing UniversitySchool of Chemistry and Chemical EngineeringNanjingChina Nanjing UniversitySchool of Electronic Science and EngineeringNanjingChina 

出 版 物：《Advanced Photonics》 (先进光子学（英文）)

年 卷 期：2022年第4卷第1期

页      面：62-68页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080202[工学-机械电子工程] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 

基　　金：sponsored by the National Natural Science Foundation of China (Nos. 61925502 and 62135007) 

主　　题：fiber nanogratings label-free sensor apoptosis monitoring 

摘      要：The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular ***,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living *** of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell *** strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering.