Application of contrast-enhanced ultrasound in minimally invasive ablation of benign thyroid nodules

作     者：Jiaying Cao Peili Fan Feihang Wang Shuainan Shi Lingxiao Liu Zhiping Yan Yi Dong Wenping Wang 

作者机构：Department of UltrasoundZhongshan HospitalFudan UniversityShanghaiChina Department of Interventional RadiologyZhongshan HospitalFudan UniversityShanghaiChina Shanghai Institute of Medical ImagingShanghaiChina 

出 版 物：《Journal of Interventional Medicine》 (介入医学杂志（英文）)

年 卷 期：2022年第5卷第1期

页      面：32-36页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(Grant No.81501471) Clinical Research Plan of SHDC(Grant No.SHDC2020CR1031B,SHDC2020CR4060) Shanghai Municipal Key Clinical Specialty(Grant No.shslczdzk03501)。 

主　　题：Ultrasound Contrast agent Thyroid Microwave ablation Radiofrequency ablation 

摘      要：Objective:This study aimed to investigate the application value of contrast-enhanced ultrasound(CEUS)before and after minimally invasive ablation procedures for benign thyroid nodule(s)(BTN).Methods:This prospective study included patients with BTNs scheduled to undergo ultrasound-guided minimally invasive ablation treatment.CEUS was performed before and after ablation(at 1 day,and 1,6,and 12 months after ablation).Changes in microvascular perfusion and the volume of BTNs were noted and assessed.Results:Sixty-two patients(62 BTNs),who underwent ablation procedures between June 2016 and August 2020,were included.All lesions were confirmed by biopsy,and histopathological results were obtained before ablation treatment.On preoperative CEUS,the lesions exhibited hyperenhancement(53.23%)or iso-enhancement(46.77%)during the arterial phase,and all lesions exhibited iso-enhancement in the venous and late phases.One day after ablation,none of the BTNs exhibited obvious enhancement on CEUS.One(1.61%)lesion was retreated due to a nodule-like enhancement area detected by CEUS at the 6-month follow-up.The mean nodular volume reduction rate(VRR)at 1,6,and 12 months follow-up demonstrated no significant difference between the two ablation groups(microwave ablation versus radiofrequency ablation).Twelve months after ablation,the mean(±SD)VRR of all BTNs was 60.3±10.3%.Conclusion:CEUS helped guide treatment decisions for BTNs before ablation treatment.Moreover,it could also be used to accurately and noninvasively evaluate treatment efficacy.