Do clinical factors help to predict disease course in inflammatory bowel disease?

作     者：Edouard Louis Jacques Belaiche Catherine Reenaers 

作者机构：Department of GastroenterologyCHU Liègeand GIGA ResearchLiège University4000 LiègeBelgium 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第21期

页      面：2600-2603页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Crohn’s disease Ulcerative colitis Clinical predictors 

摘      要：While therapeutic strategies able to change the natural history of the disease are developing,it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic *** predictors have probably been the most broadly *** both Crohn s disease(CD) and ulcerative colitis(UC),age at diagnosis,disease location and smoking habit are currently the strongest predictors of disease course.A younger age at onset is associated with more aggressive disease both in CD and *** location in CD is associated with different types of complications:surgery and recurrence in upper gastrointestinal and proximal small bowel disease;and surgery in distal small bowel disease and peri-anal lesions in rectal *** UC,extensive colitis is clearly been associated with more severe ***,active smoking globally increases disease severity in CD but decreases it in *** these important factors,others may predispose to some specific disease evolution and complications,and are also reviewed in the present paper.