Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction
作者机构：State Key Laboratory of Primate Biomedical Research and Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical ResearchKunming 650500China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第11期
页 面：1409-1419页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：the National Natural Science Foundation of China(81930121 and 82125008) the National Key Research and Development Program of China(2018YFA0107902 and 2018YFA0801403) the Major Basic Research Project of Science and Technology of Yunnan Province,China(202001BC070001)
主 题：Neural tube Organoid Neural tube defect
摘 要：It is clear that organoids are useful for studying the structure as well as the functions of organs and tissues;they are able to simulate cell-to-cell interactions,symmetrical and asymmetric division,proliferation,and migration of different cell *** progress has been made using brain organoids to elucidate the genetic basis of certain neurodevelopmental *** as Parkinson’s disease and Alzheimer’s ***,research on organoids in early neural development has received insufficient attention,especially that focusing on neural tube *** this review,we focus on the recent research progress on neural tube organoids and discuss both their challenges and potential solutions.
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