Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis:a pilot study

作     者：Ningbo Yu Siquan Liang Jiewei Lu Zhilin Shu Haitao Li Yang Yu Jialing Wu Jianda Han Yu Ningbo;Liang Siquan;Lu Jiewei;Shu Zhilin;Li Haitao;Yu Yang;Wu Jialing;Han Jianda

作者机构：College of Artificial IntelligenceNankai UniversityTianjinChina Tianjin Key Laboratory of Intelligent RoboticsNankai UniversityTianjinChina Department of NeurosurgeryTianjin Huanhu HospitalTianjinChina Department of NeurorehabilitationTianjin Huanhu HospitalTianjinChina Department of NeurologyTianjin Huanhu HospitalTianjinChina Laboratory of Cerebral Vascular and Neurodegenerative DiseasesTianjin Neurosurgical InstituteTianjin Huanhu HospitalTianjinChina 

出 版 物：《Chinese Neurosurgical Journal》 (中华神经外科杂志（英文）)

年 卷 期：2021年第7卷第3期

页      面：171-181页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 100204[医学-神经病学] 10[医学] 1009[医学-特种医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(U1913208,61873135,61720106012) the fundamental research funds for the central universities. 

主　　题：Deep brain stimulation programming Parkinson’s disease Brain efficiency Functional connectivity 

摘      要：Background:Deep brain stimulation(DBS)has proved effective for Parkinson’s disease(PD),but the identification of stimulation parameters relies on doctors’subjective judgment on patient behavior.Methods:Five PD patients performed 10-meter walking tasks under different brain stimulation frequencies.During walking tests,a wearable functional near-infrared spectroscopy(fNIRS)system was used to measure the concentration change of oxygenated hemoglobin(ΔHbO_(2))in prefrontal cortex,parietal lobe and occipital lobe.Brain functional connectivity and global efficiency were calculated to quantify the brain activities.Results:We discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters,and the DBS pattern enabling the highest brain efficiency was optimal for each patient,in accordance with the clinical assessments and DBS treatment decision made by the doctors.Conclusions:Task fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS treatment.Trial registration:Name:Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson’s disease.Registration number is ChiCTR1900022715.Date of registration is April 23,2019.