Next-Generation Sequencing-Based Diagnosis of Bacteremic Listeria monocytogenes Meningitis in a Patient with Anti-Interferon Gamma Autoantibodies:A Case Report
作者机构：Department of Clinical Microbiology and Infection ControlThe University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of MicrobiologyThe University of Hong KongHong KongChina Department of PathologyThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina
出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)
年 卷 期：2022年第4卷第1期
页 面：44-46页
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Listeria monocytogenes meningitis anti-interferon gamma autoantibody next-generation sequencing
摘 要：Although various opportunistic infections have been described in patients with anti-interferon gamma autoantibodies,so far there is no Listeria monocytogenes infection reported to be associated with this primary immunodeficiency.Here,we describe the first case of bacteremic L.monocytogenes meningitis in a 59-year-old Chinese man with anti-interferon gamma autoantibodies,who presented with acute onset of fever and severe headache.Blood culture was positive but culture of the cerebrospinal fluid was negative,although it showed features suggestive of partially treated bacterial meningitis.The presence of L.monocytogenes in the cerebrospinal fluid was confirmed by next-generation sequencing.Avoidance of high-risk food items in these patients is important for the prevention of listeriosis.The use of antibiotic regimens that cover Listeria is crucial for empirical treatment,particularly if such patients develop acute or subacute meningitis.Next-generation sequencing is becoming an important diagnostic modality for culture-negative infections.
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