Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid
作者机构：Department of Plastic SurgeryPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Plastic SurgeryPeking Union Medical College HospitalBeijingChina
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2022年第10卷第1期
页 面：432-451页
核心收录：
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：supported by The National Natural Science Foundation of China(81871538) Beijing Municipal Commission of Science and Technology(Z191100006619009)
主 题：Tumor signatures Keloid Proteome Epigenetics Exosomes Tumor biomolecules Biomarkers
摘 要：Keloid scarring is a kind of pathological healing manifestation after skin injury and possesses various tumor properties,such as the Warburg effect,epithelial-mesenchymal transition(EMT),expression imbalances of apoptosis-related genes and the presence of stem *** expression of tumor signatures is critical to the initiation and operation of these *** previous experimental studies have recognized the potential value of a single or several tumor biomolecules in keloids,a comprehensive evaluation system for multiple tumor signatures in keloid scarring is still *** paper aims to summarize tumor biomolecules in keloids from the perspectives of liquid biopsy,genetics,proteomics and epigenetics and to investigate their mechanisms of action and feasibility from bench to *** biopsy is suitable for the early screening of people with keloids due to its noninvasive and accurate *** biomarkers do not require changes in the gene sequence and their reversibility and tissue specificity make them ideal therapeutic ***,given the ethnic specificity and genetic predisposition of keloids,more large-sample multicenter studies are indispensable for determining the prevalence of these signatures and for establishing diagnostic criteria and therapeutic efficacy estimations based on these molecules.
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