Impedance Imaging of Cells and Tissues:Design and Applications
作者机构：ETH ZürichDepartment of Biosystems Science and EngineeringBaselSwitzerland
出 版 物：《Biomedical Engineering Frontiers》 (生物医学工程前沿（英文）)
年 卷 期：2022年第3卷第1期
页 面：219-239页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the European Research Council Advanced Grant 694829“neuroXscales” by the Swiss National Science Foundation under Contracts 205320_188910 and CR32I2_166329 and a Marie Heim-Vögtlin grant to R.B by an ETH Postdoctoral Fellowship to F.C
主 题：impedance microelectrode analysis
摘 要：Due to their label-free and noninvasive nature,impedance measurements have attracted increasing interest in biological *** in microfabrication and integrated-circuit technology have opened a route to using large-scale microelectrode arrays for real-time,high-spatiotemporal-resolution impedance measurements of biological *** this review,we discuss different methods and applications of measuring impedance for cell and tissue analysis with a focus on impedance imaging with microelectrode arrays in in vitro *** first introduce how electrode configurations and the frequency range of the impedance analysis determine the information that can be *** then delve into relevant circuit topologies that can be used to implement impedance measurements and their characteristic features,such as resolution and data-acquisition ***,we detail design considerations for the implementation of new impedance-imaging *** conclude by discussing future fields of application of impedance imaging in biomedical research,in particular applications where optical imaging is not possible,such as monitoring of ex vivo tissue slices or microelectrode-based brain implants.
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