CuS-PNIPAm nanoparticles with the ability to initiatively capture bacteria for photothermal treatment of infected skin

作     者：Zizhen Wang Zishuo Hou Peiwen Wang Fan Chen Xianglin Luo 

作者机构：College of Polymer Science and EngineeringSichuan UniversityChengduPeople’s Republic of China State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduPeople’s Republic of China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：347-359页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(no.51973130) by the International Cooperation and Exchange in Science and Technology Research Project of Sichuan Province(2021YFH0087) 

主　　题：capturing bacteria wound healing acceleration photothermal ablation ion-controlled release 

摘      要：Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering *** NPs,with the ability to actively capture and kill bacteria and without the worry of biocompatibility,will greatly expand their ***,a four-arm star thermosensitive polyisopropylacrylamide(4sPNIPAm)was used to modify CuS NPs(CuS-PNIPAm NPs).The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS *** of CuS-PNIPAm NPs at above 34℃resulted in capturing bacteria by forming the aggregates of *** Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in ***,CuS-PNIPAm NPs were verified to be a photothermal agent without toxic *** in vivo experiment,the NPs effectively killed the bacteria in the wound and accelerated the process of wound ***,photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria,and has a potential in the treatment of infected skin and the regeneration of skin *** therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds.