Proteomics analysis of the hypothalamus of high-fat diet fed mice after Lactiplantibacillus plantarum Y44 administration
作者机构：School of Food Science and TechnologyDalian Polytechnic UniversityLiaoning116000People's Republic of China Food Science InstituteZhejiang Academy of Agricultural SciencesHangzhou310021People's Republic of China
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2022年第47卷第3期
页 面：1166-1176页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：financially supported by the National Natural Science Foundation of China(No.31671828)
主 题：High-fat diet Lactiplantibacillus plantarum Proteomic
摘 要：Probiotics could regulate human health via changing gut *** previous studies found that Lactiplantibacillus plantarum Y44 (*** Y44) was shown to reverse obesity-related symptoms of high-fat diet fed mice by influencing gut microbiota,which ameliorated lipid metabolism disorders and intestinal *** this study,the effects of *** Y44 on high-fat fed mice and the involved mechanisms were investigated through hypothalamus proteomics analysis,which revealed 22 downregulated and 21 upregulated *** expressed proteins between *** Y44 intervention group and high-fat fed group in hypothalamus of mice involved in metabolic pathways were concentrated in endocrine regulation of carbohydrate,amino acid and energy generation *** hypothalamus proteomics results about the influences on most of differentially expressed proteins of *** Y44 administering high-fat fed mice has been ***,*** Y44 would be a potential functional strain for the amelioration of high-fat diet associated health problems.
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