Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death

作     者：Lvqin Fu Xianbin Ma Yuantong Liu Zhigang Xu Zhijun Sun Lvqin Fu;Xianbin Ma;Yuantong Liu;Zhigang Xu;Zhijun Sun

作者机构：The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool&Hospital of StomatologyWuhan UniversityWuhan 430079China Key Laboratory of Luminescence Analysis and Molecular SensingMinistry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第4期

页      面：1718-1728页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学] 0702[理学-物理学] 

基　　金：financially supported by National Natural Science Foundation of China[Nos.82072996(Z.Sun.),81874131(Z.Sun),51703187(Z.Xu)] National Key Research and Development Program(No.2017YFSF090107) the Chongqing Talent Plan for Young Top Notch Talents(No.CQYC202005029) Hubei Province Natural Science Funds for Distinguished Young Scholar[No.2017CFA062(Z.Sun)] Innovative Research Team of High-level Local Universities in Shanghai[No.ZLCX20180500(Z.Sun)]. 

主　　题：Immunogenic cell death Nanotechnology Cancer immunotherapy Combination therapy Immune checkpoint blockade 

摘      要：Tumor immunotherapy,especially immune checkpoint blockade(ICB),has revolutionized the cancer field.However,the limited response of tumors to immunotherapy is a major obstacle.Tumor immunogenic cell death(ICD)is a death mode of tumor cells that can promote tumor immunity.ICD can induce strong an-titumor immune responses through the ectopic exposure of calreticulin on the plasma membrane surface and the release of the non-histone nuclear protein high-mobility group box 1(HMGB1),ATP,and in-terferon(IFN),thus activating an adaptive immune response against dead cell-associated antigens and enhancing the therapeutic effect of tumor immunotherapy.Chemotherapy,radiotherapy,photothermal therapy,magneto-thermodynamics therapy,nanopulse stimulation,and oncolytic virus therapy can all induce a strong antitumor immune response by ICD.In addition,the application of nanotechnology can precisely target drug delivery and improve the efficacy of immunotherapy.Here we introduce the basic concepts and molecular mechanisms underlying the induction of ICD.Then,we summarize and discuss the progress in the application of nanotechnology in immunotherapy to promote ICD.Finally,we attempt to define the challenges and future directions in this area to extend the benefits of ICD to a broader patient population.