Effects of C2 hemisection on respiratory and cardiovascular functions in rats

作     者：Pauline Michel-Flutot Arnaud Mansart Abdallah Fayssoil Stéphane Vinit Pauline Michel-Flutot;Arnaud Mansart;Abdallah Fayssoil;Stéphane Vinit

作者机构：UniversitéParis-SaclayUVSQInsermEND-ICAPVersaillesFrance UniversitéParis-SaclayUVSQInsermInfection et Inflammation(2I)VersaillesFrance Raymond PoincaréHospitalAP-HPGarchesFrance 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第2期

页      面：428-433页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by funding from the Chancellerie des Universites de Paris(Legs Poix)(to SV) Fondation Medisite(to SV) INSERM(to SV,AM,AF) Universite de Versailles Saint-Quentin-en-Yvelines(to SV,AM,AF)。 

主　　题：C2 spinal cord injury cardiovascular diaphragm activity heart function hemiplegia rat model respiratory ultrasound 

摘      要：High ce rvical spinal co rd injuries induce permanent neuromotor and autonomic deficits.These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system.So far,cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels and diaphragm activity evaluations using invasive methods.The present study aimed to evaluate the impact of C2 hemisection on different parameters representing vital functions(i.e.,respiratory function,cardiovascular,and renal filtration parameters)at the moment of injury and 7 days post-injury in rats.No ventilatory parameters evaluated by plethys mography were impacted during quiet breathing after 7 days post-injury,whereas permanent diaphragm hemiplegia was observed by ultrasound and confirmed by diaphragmatic electromyography in anesthetized rats.Interestingly,the mean arterial pressure was reduced immediately after C2 hemisection,with complete compensation at 7 days post-injury.Renal filtration was unaffected at 7 days post-injury;however,remnant systolic dysfunction chara cterized by a reduced left ventricular ejection fraction persisted at 7 days post-injury.Taken together,these results demonstrated that following C2 hemisection,diaphragm activity and systolic function are impa cted up to 7 days post-injury,whereas the respiratory and cardiovascular systems display vast ada ptation to maintain ventilatory parameters and blood pressure homeostasis,with the latter likely sustained by the remaining descending sympathetic inputs spared by the initial injury.A better broad characterization of the physiopathology of high cervical spinal cord injuries covering a longer time period post-injury could be beneficial for understanding evaluations of putative therapeutics to further increase cardiorespiratory recovery.