Assessment of the anti-tumor activity of cyanidin-3-O-arabinoside from apple against APN,JAK,and EZH2 target proteins

作     者：Dan Zhang Zhipeng Yu Wenzhu Zhao Jingbo Liu 

作者机构：School of Food Science and EngineeringHainan UniversityHaikou570228PR China College of Food Science and EngineeringDalian Polytechnic UniversityDalian116034LiaoningPR China Laboratory of Nutrition and Functional FoodJilin UniversityChangchun130062JilinPR China 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2022年第48卷第4期

页      面：378-386页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by The China Scholarship Council(Grant No.202008210142) the Open Fund of Key Laboratory of Fruit and Vegetable Processing,Ministry of Agriculture and Rural Affairs,China(Grant No.FVKF2020002) 

主　　题：Apple polyphenols Cyanidin-3-O-arabinoside Caco-2 cell Anti-tumor 

摘      要：This study aimed to evaluate the anti-tumor activity and the mechanism of apple polyphenols on aminopeptidase N(APN),janus kinase 3(JAK3)and enhancer of zeste homolog 2(EZH2)using molecular docking and in vitro human colon(Caco-2)*** 88 apple polyphenols were docked with targets,i.e.,APN,JAK3,and EZH2,and the potential polyphenol cyanidin-3-O-arabinoside was ***-8 assay results showed that cyanidin-3-O-arabinoside exerted a significant inhibitory effect on the proliferation of Caco-2 cells,with an IC50 value of 112±4.36μg mL-1 at 72 *** indicated that cyanidin-3-O-glucoside can block S phase to induce cell apoptosis by influencing S phase and the expression of Bcl-2 and *** summary,cyanidin-3-O-glucoside from apple polyphenols may be used as a potential inhibitor to prevent colon cancer.