Structure,function,and pathology of Neurexin-3
作者机构：Chongqing Key Laboratory of NeurobiologyChongqing Medical UniversityChongqing 400016China Department of NeurologyThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of AnatomyChongqing Medical UniversityChongqing 400016China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第5期
页 面：1908-1919页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：Excitatory synapses Inhibitory synapses Neural cell adhesion molecules Neurexin-3 Neurodegenerative diseases Neuropsychiatric diseases
摘 要：Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic ***-3 has important roles in synapse development and synapse ***-3 mediates excitatory presynaptic differentiation by interacting with leucine-rich-repeat transmembrane neuronal ***,neurexin-3 modulates the expression of presynapticα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors andγ-aminobutyric acid A receptors by interacting with neuroligins at excitatory and inhibitory *** studies have documented the potential contribution of neurexin-3 to neurodegenerative and neuropsychiatric disorders,such as Alzheimer s disease,addiction behaviors,and other diseases,which raises hopes that understanding the mechanisms of neurexin-3 may hold the key to developing new strategies for related *** review comprehensively covers the literature to provide current knowledge of the structure,function,and clinical role of neurexin-3.
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