Platinum-Catalyzed Allylic C-H Alkylation with Malononitriles

作     者：Lian-Feng Fan Pei-Pei Xie Pu-Sheng Wang Xin Hong Liu-Zhu Gong 

作者机构：Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryUniversity of Science and Technology of ChinaHefei 230026 Department of ChemistryZhejiang UniversityHangzhou 310027 Center for Excellence in Molecular Synthesis of Chinese Academy of SciencesHefei 230026 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第4期

页      面：1366-1375页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：The financial support from the National Nature Science Foundation of China(NSFC)(nos.21831007 and 21672197 for L.-Z.G.and nos.21702182 and 21873081 for X.H.) the Chinese Academy of Sciences(grant no.XDB20020000) Youth Innovation Promotion Association CAS,Fundamental Research Funds for the Central Universities(no.2020XZZX002-02 for X.H.) the State Key Laboratory of Clean Energy Utilization(no.ZJUCEU2020007 for X.H.)is gratefully acknowledged 

主　　题：platinum catalysis phosphoramidite C-H activation allylic alkylation concerted proton and two-electron transfer 

摘      要：The direct functionalization of allylic C-H bonds is distinguished by enabling rapid assembly of structural complexity from simple *** Pd-catalyzed allylic C-H functionalization has been extensively studied,the discovery of new catalytic systems remains fairly ***,we disclose a Pt-catalyzed allylic C-H alkylation of a wide range of α-alkenes by using phosphoramidites as ligands and malononitriles as alkylating ***,the combination of chiral ureacatalyzed Michael addition and Pt-catalyzed allylic C-H alkylation can serve as an efficient protocol to access chiral tetrahydropyran with high levels of diastereo-and *** studies suggest that the Pt-catalyzed allylic C-H activation proceeds through a concerted proton and two-electron transfer process,which is analogous to transition state geometries of Pd catalysis.