Histone post-translational modification and the DNA damage response

作     者：Haoyun Song Rong Shen Xiangwen Liu Xuguang Yang Kun Xie Zhao Guo Degui Wang Haoyun Song;Rong Shen;Xiangwen Liu;Xuguang Yang;Kun Xie;Zhao Guo;Degui Wang

作者机构：School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第4期

页      面：1429-1444页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by National Natural Science Foundation of China(No.82071695,82060535) Natural Science Foundation of Gansu Province,China(No.21JR7RA450) 

主　　题：DNA damage DNA damage response Histone Post-translational modifications(PTMs) 

摘      要：DNA is highly vulnerable to spontaneous and environmental timely damage in living *** damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and *** cells possess several DNA damage response(DDR)mechanisms to protect the integrity of their *** of the mechanisms under-lying the DNA damage response following lethal damage will facilitate the identification of therapeutic targets for *** post-translational modifications(PTMs)have been indicated to play different roles in the repair of DNA *** this context,histone PTMs regulate recruitment of downstream effectors,and facilitate appropriate repair *** review outlines the current understanding of different histone PTMs in response to DNA dam-age repair,besides,enumerates the role of new type PTMs such as histone succinylation and crotonylation in regulating DNA damage repair processes.