Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells

作     者：Jia-Lin Zhan Yan-Ling Huang Qiao-Wen Liang Xiao-Sheng Qu Zi-Mei Dong Yi Du Wen-Jing Luo Jia-Lin Zhan;Yan-Ling Huang;Qiao-Wen Liang;Xiao-Sheng Qu;Zi-Mei Dong;Yi Du;Wen-Jing Luo

作者机构：Department of Ophthalmologythe First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina National Engineering Laboratory of Southwest Endangered Medicinal Resources DevelopmentGuangxi Botanical Garden of Medicinal PlantsNanningGuangxi Zhuang Autonomous RegionChina Department of Neurologythe People’s Hospital of Chuxiong Yi Autonomous PrefectureChuxiong Yi Autonomous PrefectureYunnan ProvinceChina Department of Neurologythe First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第2期

页      面：451-455页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81560162 the Guangxi Natural Science Foundation of China,No.2018GXNSFAA050052(both YD)。 

主　　题：aquaporin-4 corticosteroids inflammation microRNA neuroprotection oligodendrocyte optic neuropathy regulatory T cells Th17 cell visual field defect 

摘      要：Methylprednisolone pulse treatment is currently used fo r optic neuritis.It can speed visual recovery,but does not improve the ultimate visual outcomes.Recent studies have repo rted that miR-125 a-5 p has immunomodulatory effects on autoimmune diseases.However,it remains unclear whether miR-125 a-5 p has effects on optic neuritis.In this study,we used adeno-associated virus to overexpress or silence miR-125 a-5 p in mice.We found that silencing miR-125 a-5 p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve.Ove rexpression of miR-125 a-5 p suppressed inflammation of the optic nerve,protected retinal ganglion cells,and increased the percentage of Treg cells.Our findings show that miR-125 a-5 p exhibits anti-inflammatory effects through promoting the diffe rentiation of Treg cells.