Intra-set correlation analysis of medical records of thyroid cancer treated by traditional Chinese medicine Master ZHOU Zhongying

作     者：XU Ziyuan ZHU Yao LU Ming ZHOU Zhongying 徐子缘;朱垚;陆明;周仲瑛

作者机构：The First Clinical Medical CollegeNanjing University of Chinese MedicineNanjingJiangsu 210023China Data Mining CenterMedchitec Co.Ltd.NanjingJiangsu 210009China 

出 版 物：《Digital Chinese Medicine》 (数字中医药（英文）)

年 卷 期：2022年第5卷第2期

页      面：141-153页

学科分类：12[管理学] 1006[医学-中西医结合] 1005[医学-中医学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 100502[医学-中医临床基础] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Six Talent Peak Projects in Jiangsu Province (RJFW-40) Jiangsu Province “333 High-level Talent Training Project”(2018Ⅲ-0121) Technology Innovation Fund of Science and Technology Enterprises in Jiangsu Province (BC2015022) Representative Project of Intangible Cultural Heritage in Pukou District,Nanjing (PKIX-4) The Construction and Application of Thyroid Disease Differentiation and Treatment Rule Mining and Clinical Decision Support System by Traditional Chinese Medicine Master ZHOU Zhongying (012071003583) 

主　　题：Traditional Chinese medicine Master ZHOU Zhongying Thyroid cancer Empirical analysis Data mining Intra-set association Phlegm and blood stasis Damp-heat accumulation Combination of attack and supplement 

摘      要：Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medical records of traditional Chinese medicine(TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experience in “mechanism-syndrome-medicine-prescription for thyroid *** Through Medcase data processing platform, based on Frequent Pattern(FP)-Growth enhanced correlation analysis algorithm, the medical records of Professor ZHOU Zhongying for the treatment of thyroid cancer from June 1, 2001 to February 28, 2015 were analyzed within the *** This study involved 43 medical records, 43 patients, and 167 visits. After processing intra-set correlations, 28 groups of highly correlated symptoms, 21 groups of highly correlated tongue images, 10 groups of highly correlated pulse conditions, 28 groups of highly correlated pathogenesis, 34 groups of highly correlated herbs, and 26 groups of highly correlated western medicine diagnosis were selected. Professor ZHOU Zhongying treats thyroid cancer according to syndrome differentiation. Symptoms with more association rules included neck swelling, neck pain, cough, and dry mouth;tongue images with more association rules included dark purple tongue, dark red tongue, and fissured tongue;pulse conditions with more association rules were wiry pulse, thready pulse, small pulse, and slippery pulse;the pathogenesis with more association rules was phlegm and blood stasis, damp-heat accumulation,and impairment of both Qi and Yin;herbs with more association rules were Chaihu(Bupleuri Radix), Zeqi(Sun Euphoribiae Herb), and Tiandong(Asparagi Radix);western medicine diagnosis with more association rules included thyroid cancer, insomnia, and chronic *** Thyroid cancer mostly presents as deficiency in origin and excess in manifestations. The basic pathogenesis is phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin, which are closely related to liver, kidney, and spleen. P