Expert consensus on the role of hematological markers in the earlyclinical screening of hepatocellular carcinoma

作     者：Infectious diseases branch of Chinese Preventive Medicine Association Infectious diseases branch of Chinese Preventive Medicine Association

作者机构：Infectious diseases branch of Chinese Preventive Medicine Association 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2022年第6卷第2期

页      面：66-71页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatocellular carcinoma(HCC) Early screening Hematological marker Alpha-fetoprotein(AFP) Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3) Des-gamma-carboxyprothrombin(DCP) Expert consensus 

摘      要：The disease burden of hepatocellular carcinoma (HCC) in China is heavy, and the prognosis is stillunfavourable. Therefore, early screening of high-risk groups of HCC through simple methods is the key toachieving early diagnosis and treatment and improving survival. At present, alpha-fetoprotein and otherhematological tests are still the main methods in the early screening of HCC, but the sensitivity andspecificity are limited, and the risk of missed diagnosis is high. In recent years, with the continuousdevelopment of science and technology, the improvement of traditional detection methods and theemergence of novel markers such as methylated deoxyribonucleic acid and microRNA have brought hopefor further improving the sensitivity and specificity of early HCC screening. This consensus summarizesthe research progress of traditional and new hematological test methods and puts forward expertguidance on the role of hematological markers in the early screening of HCC to provide a basis forimproving the prevention and control level in China.