Efficacy and Safety of Aspirin for Prevention of Hepatocellular Carcinoma:An Updated Meta-analysis
作者机构：Department of General SurgeryQilu HospitalShandong UniversityJinanShandongChina Department of Hepatobiliary SurgeryThe second Hospital of Shandong UniversityJinanShandongChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第5期
页 面：835-846页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the grants from the Taishan Scholars Program for Young Expert of Shandong Province(Grant no.tsqn20161064) National Natural Science Foundation of China(Grant nos.82073200 and 81874178) funds for Independent Cultivation of Innovative Team from Universities in Jinan(Grant no.2020GXRC023)
主 题：Aspirin Hepatocellular carcinoma Prevention Meta-analysis Doseresponse analysis
摘 要：Background and Aims:Previous meta-analyses have shown that aspirin use may reduce the risk of hepatocellular carcinoma(HCC).However,the optimal dose,frequency,and duration of aspirin use or the safety and efficacy of aspirin in target populations for HCC prevention remain *** study aim was to investigate the efficacy and safety of aspirin for prevention of ***:Publications were retrieved by a comprehensive literature research of several *** on a random-effects model,hazard ratios(HRs)and the corresponding 95%confidence intervals(CIs)were used to assess the pooled *** dose-response relationship between aspirin use and HCC risk was assessed with a restricted cubic spline ***:Twenty-two studies were included in the *** use was associated with a reduced risk of HCC(HR=0.64,95%CI:0.56–0.75).The effect was robust across sex and age;however,women and the non-elderly had the greatest benefit from aspirin *** preventive effect was well reproduced in those with *** use and long-term use of aspirin appeared to offer greater *** 100 mg/d was associated with maximum reduction of HCC *** use did slightly increase the risk of bleeding(HR=1.14,95%CI:1.02–1.27).Conclusions:Our meta-analysis confirmed that use of aspirin significantly reduced the incident risk of *** and long-term aspirin use offers a greater *** use was associated with an increased risk of *** recommend 100 mg/d aspirin as a feasible dose for further research on primary prevention of HCC in a broad at-risk population.
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