Identification of SARS-CoV-2 by gold nanoparticles

作     者：LORIS RIZZELLO VALERIA DE MATTEIS 

作者机构：Department of Pharmaceutical SciencesUniversity of MilanMilano20133Italy National Institute of Molecular Genetics(INGM)Milano20122Italy Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and TechnologyBarcelona08028Spain Department of Mathematics and Physics“Ennio De Giorgi”via per ArnesanoLecce73100Italy 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第11期

页      面：2369-2380页

核心收录：

学科分类：0710[理学-生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：V.D.M.kindly acknowledges Programma Operativo Nazionale(PON)Ricerca e Innovazione 2014-20202014-azione IV.6“Contratti su tematiche green”-DM 1062/2021 for sponsoring her salary and work.L.R.kindly acknowledges the ERC-2019-StG(Grant No.850936)and Fondazione Cariplo(Grant No.2019-4278)for supporting his research activities 

主　　题：SARS-CoV-2 Gold nanoparticles Diagnosis Therapy Physicochemical properties Pandemic disease 

摘      要：The SARS-CoV-2 outbreaks highlighted the need for effective,reliable,fast,easy-to-do and cheap diagnostics *** pragmatically experienced that an early positive-case detection,inevitably coupled with a mass vaccination campaign,is a milestone to control the COVID-19 *** nanoparticles(AuNPs)can indeed play a crucial role in this context,as their physicochemical,optics and electronics properties are being extensively used in photothermal therapy(PTT),radiation therapy(RT),drug delivery and *** can be synthesized by several approaches to obtain different sizes and shapes that can be easily functionalized with many kinds of molecules such as antibodies,proteins,probes,and *** addition,AuNPs showed high biocompatibility making them useful tool in medicine *** thus reviewed here the most relevant evidence on AuNPs as effective way to detect the presence of SARS-CoV-2 *** trust future diagnostic efforts must take this‘old-fashioned’nanotechnology tool into consideration for the development and commercialization of reliable and feasible detection kits.