Radical-Mediated Selective Functionalization of Unactivated Primary C-H Bonds

作     者：Zhan-Lin Wang Fei Wang Zhan-Lin Wang;Fei Wang

作者机构：State Key Laboratory of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin 300071China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第14期

页      面：1751-1753页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support from the National Natural Science Foundation of China(No.22101140) the Fundamental Research Funds for the Central Universities(No.63213059) the startup funds from Nankai University 

主　　题：C-H activation Hydrogen atom transfer Radical reactions Regioselectivity Steric hindrance 

摘      要：Radical-mediated sp^(3)C—H functionalization has found broad applications in synthesis and late-stage derivatization of complex *** site-selectivity of a given reaction is mainly dictated by the bond strength,polarity and steric accessibility of diverse C—H bonds as well as the characters of hydrogen atom *** sp^(3)C—H bonds usually follow the relative reactivity sequence of tertiarysecondaryprimary,which is even recognized as the innate preferences of certain *** development of innovative methods capable of overriding the“inherentsite-selectivity is exceedingly *** it has been demonstrated that secondary C—H bonds could be selectively converted in the presence of weaker tertiary C—H bonds by tuning the steric and electronic properties of hydrogen atom acceptors,the selective activation of primary C—H bonds remains a daunting ***,we highlight the recently emerging attempts towards this goal by interrogating the steric effect of hydrogen atom acceptors.