Sulfation modification of dopamine in brain regulates aggregative behavior of animals

作     者：Bing Chen Xiwen Tong Xia Zhang Wanying Gui Guoming Ai Lihua Huang Ding Ding Jiangxu Zhang Le Kang Bing Chen;Xiwen Tong;Xia Zhang;Wanying Gui;Guoming Ai;Lihua Huang;Ding Ding;Jiangxu Zhang;Le Kang

作者机构：School of Life ScienceInstitutes of Life Science and Green DevelopmentHebei University State Key Laboratory of Integrated Management of Pest Insects and RodentsInstitute of ZoologyChinese Academy of Sciences School of Life SciencesSouth China Normal University State Key Laboratory of Microbial ResourcesInstitute of MicrobiologyChinese Academy of Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2022年第9卷第4期

页      面：60-75页

核心收录：

学科分类：0402[教育学-心理学(可授教育学、理学学位）] 0303[法学-社会学] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 0703[理学-化学] 0702[理学-物理学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：supported by the National Natural Science Foundation of China (31872304 and 31661143048) the Science and Technology Project of Hebei Education Department(SLRC2019019) 

主　　题：behavioral plasticity sulfation dopamine aggregation migratory locust 

摘      要：Behavioral plasticity and the underlying neuronal plasticity represent a fundamental capacity of animals to cope with environmental *** plasticity is controlled by complex molecular networks that act under different layers of *** various molecules have been found to be involved in the regulation of plastic behaviors across species,less is known about how organisms orchestrate the activity of these molecules as part of a coherent behavioral response to varying *** we discover a me chanism for the regulation of animal behavioral plasticity involving molecular sulfation in the brain,a modification of substrate molecules by sulfo transferase(ST)-catalyzed addition of a sulfonate group(SO3)from an obligate donor,3’-phosphoadenosine 5’-phosphosulfate(PAPS) to the *** investigated aggregation behaviors of migratory locusts,which are well-known for extreme phase change plasticity triggered by population *** processes of PAPS biosynthesis acted efficiently on induction of locust behavioral transition:Inhibition of PAPS synthesis solicited a behavioral shift from gregarious to solitarious states;external PAPS dosage,by contrast,promoted aggregation in solitarious *** or pharmacological intervention in the sulfation catalyzation resulted into pronounced solitarizing *** of substrate-specific STs suggests a widespread involvement of sulfated neurotransmitters in the behavioral response.D opamine in the brain was finally identified to be actively sulfate conjugate d,and the sulfate conjugation enhanced the free DA-mediated behavioral *** results in Caenorhabditis elegans and mice indicate that sulfation may be involved more broadly in the modulation of animal *** findings reveal a general me chanism that effectively regulates animal social-like behavioral plasticity,possibly through sulfation-mediated modification of neural networks.