Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats

作     者：Xitong Zhang Lin Du Weimin Zhang Mi Yang Li Chen Chen Hou Jianke Li Xitong Zhang;Lin Du;Weimin Zhang;Mi Yang;Li Chen;Chen Hou;Jianke Li

作者机构：College of Food Engineering and Nutritional ScienceShaanxi Normal UniversityXi’an 710119China University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value UtilizationXi’an 710119China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2022年第11卷第4期

页      面：1076-1085页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：supported by the National Natural Science Foundation of China (31871801, 32001679) the Science and Technology Research of Shaanxi Province (2020QFY08-03) Forestry Science and Technology Programs of Shaanxi Province (SXLK20200213) Fundamental Research Funds for the Central Universities (GK201604013)。 

主　　题：Metabolic syndrome Insulin resistance Insulin signaling pathway PPARγ Pomegranate peel polyphenols 

摘      要：Insulin resistance(IR) has been considered to be an important causative factor of metabolic syndrome(Met S). The present study investigated whether pomegranate peel polyphenols(PPPs) could prevent the development of Met S by improving IR in rats. Male Sprague-Dawley(SD) rats were fed high fat diet(HFD) to induce Met S and supplemented with different dosages of PPPs for 12 weeks. The results showed that HFD-induced insulin resistant rats had disordered metabolism of blood glucose, blood lipid, and terrible muscle fiber morphology when compared with normal diet-fed rats, but PPPs treatment at a dosage of 300 mg/kg·day significantly reversed these negative effects. Moreover, in skeletal muscle tissue of insulin resistant rats, PPPs treatments significantly increased the protein expressions of insulin receptor(Ins R) and phosphorylated insulin receptor substrate 1(IRS-1), stimulated peroxisome proliferator activated receptor gamma(PPARγ) and phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT/PKB) signaling pathway, and aggrandized the protein levels of phosphorylated glycogen synthase kinase-3β(GSK-3β) and glucose transporter 4(GLUT4). Our results suggest that PPPs possess of the beneficial effects on alleviating IR by enhancing insulin sensitivity and regulating glucose metabolism.